CLINICAL TRIALS AND OBSERVATIONS Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs
نویسندگان
چکیده
1Cancer Prevention and Control Division, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; 2Contractor to the National Cancer Institute (NCI), Bethesda, MD; 3Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley; 4Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston; 5Cancer Therapy Evaluation Program, NCI, Bethesda, MD; 6Surveillance Research Program, NCI, Bethesda, MD; and 7Hematologic Malignancy Division, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
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CLINICAL TRIALS AND OBSERVATIONS Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
JAK2 V617F mutation recently was identified as a pathogenic factor in typical chronic myeloproliferative diseases (CMPD). Some forms of myelodysplastic syndromes (MDS) show a significant overlap with CMPD (classified as MDS/MPD), but the diagnostic assignment may be challenging. We studied blood or bone marrow from 270 patients with MDS, MDS/MPD, and CMPD for the presence of JAK2 V617F mutation...
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The myelodysplastic syndromes (MDSs) are characterized by bilineage or trilineage dysplasia. Although diagnostic criteria are well established for MDS, a significant number of patients have blood and bone marrow findings that make diagnosis and classification difficult. Flow cytometric immunophenotyping is an accurate and highly sensitive method for detection of quantitative and qualitative abn...
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Success of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) has given patients hope for a long disease-free-survival. A longer survival raises the question of late effects, including development of another malignancy. Records of 1445 patients with CML/ myeloproliferative neoplasm or other hematologic malignancies treated with TKIs were reviewed to investigate frequency and ch...
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Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with mutation(s) in the JAK2, MPL, or CALR genes. Yet the roles played by these mut...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Clinical profile of homozygous JAK2 617V F mutation in patients with polycythemia vera or essential thrombocythemia
Alessandro M. Vannucchi,1 Elisabetta Antonioli,1 Paola Guglielmelli,1 Alessandro Rambaldi,2 Giovanni Barosi,3 Roberto Marchioli,4 Rosa Maria Marfisi,4 Guido Finazzi,2 Vittoria Guerini,2 Fabrizio Fabris,5 Maria Luigia Randi,5 Valerio De Stefano,6 Sabrina Caberlon,7 Agostino Tafuri,8 Marco Ruggeri,9 Giorgina Specchia,10 Vincenzo Liso,10 Edoardo Rossi,11 Enrico Pogliani,12 Luigi Gugliotta,13 Alber...
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